Hello! Have read a lot on this forum (ty and also the fb group) and others that NSAIDs (other than aspirin) early in postop may increase risk for AF.
But wondering if there is guidance on the role of NSAIDs outside of the immediate postop period. Seems like sometimes they may be beneficial in helping decrease inflammation and swelling especially as one progresses in PT and loading the knee in rehab for flares for shorter bursts? But want sure if even these are harmful? And whether there is a maximum duration of number of days one should aim for NSAIDs if have to take them?
What is early postop defined as? First 6 weeks? Or longer?
Are certain NSAIDs less bad or less risky for AF progression or development? Several have mentioned Celebrex vs Naproxen/ibuprofen. is there literature or evidence as to how long a burst of NSAIDs could be safe or ok for AF?
From my reading here, seems like the risk of AF is continuous (for life?) and can happen late stage postop or even years later but that the risk of developing it is highest in the first 6-8 weeks? Postop? Is this the case? Or are there high risks anytime there is inflammation from exercise or rehab?
And is there any guidance on how long to stay on 81 mg aspirin postop as well?
Thanks so much and so grateful for this group!
Hi Rick,
Well-informed doctors no longer prescribe Celebrex in the long-term because it's known to significantly increase the risk of heart and kidney disease. Both diseases are forms of fibrosis, and long-term use of an NSAID (such as Celebrex) has also been shown to increase damage in knees (see Treatments, Oral Medications).
I can't give medical advice, but if I were you, I would ask my doctor about alternative medications to help sleep, such as low-dose, slow-release aspirin or paracetamol (acetaminophen). Melatonin could also help.
All the best,
Kayley